Serum levels of il-8, il-10, il-13, ifnγ and tnfα in pediatric patients with acute infection with different dengue virus serotypes

Authors

  • Joanna Santeliz Casavilca University Centrocidental Lisandro Alavarado, Venezuela.
  • William Lopez University Centrocidental Lisandro Alavarado, Venezuela.
  • Elis Mosquera University Centrocidental Lisandro Alavarado, Venezuela.
  • Antonio Guerrero University Centrocidental Lisandro Alavarado, Venezuela.
  • Isabel Alvarez University Centrocidental Lisandro Alavarado, Venezuela.

Keywords:

Dengue, Elisa, Interleukins, PCR-TR, TH1/TH2

Abstract

Dengue is an acute febrile disease caused by four dengue virus (DENV) serotypes whose prevalence in the Americas has quintupled between 2003 and 2013. The immune response against the infection with dengue virus involves cellular and humoral factors. We performed an observational and cross-sectional study to evaluate the levels of interleukins of the innate immune response (IL-8, TNFα), TH1 response (IFNγ), TH2 (IL-13) and regulatory (IL-10) in serum of patients during the acute phase of infection with the DENV1, DENV3 and DENV4 serotypes.

Author Biographies

  • Joanna Santeliz Casavilca, University Centrocidental Lisandro Alavarado, Venezuela.
    Doctor.Specialist in Pneumonology. Teacher Titular Decanato Cs. Of the health.
    University Centroccidental Lisandro Alvarado
  • William Lopez, University Centrocidental Lisandro Alavarado, Venezuela.
    Agroindustrial Technician. Physiology section. Deanship Cs de la Salud University
    Centroccidental Lisandro Alvarado.
  • Elis Mosquera, University Centrocidental Lisandro Alavarado, Venezuela.
    Agroindustrial Technician. Physiology section. Deanship Cs de la Salud University
    Centroccidental Lisandro Alvarado
  • Antonio Guerrero, University Centrocidental Lisandro Alavarado, Venezuela.
    Technical Microbiology Section of Microbiology Dec Cs of Health Universidad Centroccidental
    Lisandro Alvarado
  • Isabel Alvarez, University Centrocidental Lisandro Alavarado, Venezuela.
    Lic. Bionalisis. Specialty in Bacterilogy. Associate Professor Microbilogia section.
    Dept. of preventive and social medicine Decanato cs de la Salud. Centroccidental University
    Lisandro Alvarado.

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Published

2018-08-03

How to Cite

Serum levels of il-8, il-10, il-13, ifnγ and tnfα in pediatric patients with acute infection with different dengue virus serotypes. (2018). Revista Venezolana de Salud Pública, 4(1), 27-32. https://revistas2.uclave.org/index.php/rvsp/article/view/1421